Postdoctoral Fellowship
Delft University of Technology
Delft, Netherlands
2-year postdoctoral fellowship
Ultrasound imaging of intraosseous blood flow in the human knee
A 2-year post-doctoral position is open at Delft University of Technology in the Netherlands, in the department of imaging physics (https://www.tudelft.nl/en/faculty-of-applied-sciences/about-faculty/departments/imphys/). Unlike common belief, we recently demonstrated that ultrasound can image the cortex of long bones and can measure pulsatile blood flow inside cortical bone tissue (https://doi.org/10.1002/jbm4.10543). This international project also involves the Laboratoire d’Imagerie Biomédicale (https://www.lib.upmc.fr/) at Sorbonne Université in Paris and Erasmus Medical Center (https://www.erasmusmc.nl) in Rotterdam, in the Netherlands.
7% of the world population suffers from osteoarthritis, the most common joint disease. No cure exists, largely due to our poor understanding of the disease. The development of biomarkers for progression and patient classification is a very active field. Intraosseous vascular alterations were demonstrated during the progression of osteoarthritis, therefore they are a potential biomarker. Unfortunately these intraosseous vascular changes are difficult to study with existing noninvasive technologies. The project aims to:
- Develop intraosseous ultrasound to detect intraosseous blood flow abnormalities in the knee
- Validate the approach in vivo with MRI on patients with knee osteoarthritis
The postdoctoral researcher will be in charge of:
- The development of an algorithm for intra-osseous image reconstruction in the knee that accounts for wave refraction and wave speed anisotropy with a matrix array transducer
- The development of an optimal pulse sequence to enable imaging of intraosseous blood flow inside the knee and its implementation on a fully programmable ultrasound scanner equipped with a matrix array transducer
- The ultrasound measurements on patients with knee osteoarthritis, their analysis and comparison with MRI
Location: Delft University of Technology, the Netherlands
Qualifications: Applicants with a PhD in medical ultrasound and/or ultrasound imaging will be considered. Taste for lab and in vivo experimental work and programming skills (Matlab, C, Cuda) are required.
Financial conditions are based on a postdoctoral salary in the Netherlands.
How to apply: Candidates are invited to contact Guillaume RENAUD for additional information and to submit their application (including letter of motivation, CV, publication list, manuscript of PhD thesis, and name and contact information of at least two referees).
Contact: Guillaume RENAUD : g.g.j.renaud@tudelft.nl